Eine Übersicht über pharmakologische Daten einiger Benzodiazepine und Vermarktungsangaben bietet die folgende Tabelle. In: Smith DE, Wesson DR, editors. A review of drug-induced acute angle closure glaucoma for non-ophthalmologists. Lee J, Lee JS, Park SH, Shin SA, Kim K. Cohort profile: the National Health Insurance Service-National Sample Cohort (NHIS-NSC), South Korea. et al. 2015;2015:6. Benzodiazepine Use and Risk of Acute Angle-Closure Glaucoma: A Population-Based Case-Crossover Study @article{Kim2020BenzodiazepineUA, title={Benzodiazepine Use and Risk of Acute Angle-Closure Glaucoma: A Population-Based Case-Crossover Study}, author={Woo Jung Kim and Junqing Li and Insun Oh and Inmyung Song and E. Lee … Int J Epidemiol. Hong Kong Med J. Woo Jung Kim, Junqing Li, In-Sun Oh, Inmyung Song, Eun Lee, Kee Namkoong, and Ju-Young Shin have no conflicts of interest that are directly relevant to the content of this study. Foto: Fotolia/vbaleha »Angesichts der vielen möglichen Ursachen eines schlechten Schlafs gibt es kein magic bullet für die Schlafförderung«, sagte der Pharmakologe. BMC Psychiatry. Pharmacopsychiatry. 4 Substanzen. 1977;134:447–8. We would like to acknowledge ophthalmologist Sang Yeop Lee, MD for his invaluable advice during discussions prior to the commencement of the study. Der ungesättigte siebengliedrige Ring enthält zwei Stickstoffatome. Diazepam sollte daher bei älteren Menschen nicht eingesetzt werden (4). Controls, people who have not been diagnosed with AACG, were randomly matched with the case according to age, sex, and index year (n = 4468). The funding agency was not involved in the study design, data collection and analysis, or manuscript preparation. We conducted a population-based case-crossover study using the nationwide claims database of the National Health Insurance Service in Korea. Benzodiazepine (BZD) als Hypnotika und Tranquilizer gehören immer noch zu den mit Abstand am häufigsten eingesetzten Psychopharmaka, auch wenn ihre Verschreibung in den letzten Jahren zum Teil zugunsten anderer Hypnotika, wie z. 46.90 € Wirkstoff: Alprazolam. However, there is no research evidence for the association between BZDs and AACG, except two case reports. 1972 Sep-Oct;2(3):400-2. Pharmacy times. Benzodiazepine Use and Risk of Acute Angle-Closure Glaucoma: A Population-Based Case-Crossover Study. Comparison between high and low potency statins in the incidence of open-angle glaucoma: A retrospective cohort study in Japanese working-age population. Sie wirken insgesamt beruhigend, erregungs- und aggressionsdämpfend, entspannend, angstlösend und schlafanstoßend. AACG risk was similar for short-acting (aOR = 1.40, 95% CI 1.24–1.57) and long-acting BZDs (aOR = 1.33, 95% CI 1.18–1.50). Google Scholar. Lachkar Y, Bouassida W. Drug-induced acute angle closure glaucoma. Abrupt cessation of benzodiazepine therapy may precipitate seizures and other withdrawal symptoms, particularly after prolonged use and/or excessive dosages. Seitz DP, Campbell RJ, Bell CM, Gill SS, Gruneir A, Herrmann N, Newman AM, Anderson G, Rochon PA. J Clin Psychopharmacol. Association of Selective Serotonin Reuptake Inhibitor Use and Acute Angle-Closure Glaucoma. Benzodiazepine Arzneimittelgruppen Benzodiazepine sind pharmazeutische Wirkstoffe mit angstlösenden, krampflösenden, beruhigenden und schlaffördernden Eigenschaften. γ-Aminobuttersäure (GABA) ist ein inhibitorischer Neurotransmitter, d.h. es hemmt die elektrische Aktivität von Nervenzellen. Unable to load your collection due to an error, Unable to load your delegates due to an error. Status epilepticus may occur in patients with a history of seizures withdrawn rapidly from benzodiazepine therapy. We aimed to investigate whether BZDs increase the risk of AACG in a geriatric population. Comprehension of top 200 prescribed drugs in the US as a resource for pharmacy teaching, training and practice. Die Benzodiazepin-Abhängigkeit wurde bereits als »Sucht der alten Damen« bezeichnet, da vorwiegend ältere Frauen betroffen sind. 2008;6:293–310. Benzodiazepine (umgangssprachliche Kurzform Benzos) sind polycyclische organische Verbindungen auf Basis eines bicyclischen Grundkörpers, in dem ein Benzol- mit einem Diazepinring verbunden ist. Curr Opin Ophthalmol. This is a preview of subscription content, access via your institution. Association between use of benzodiazepines and occurrence of acute angle-closure glaucoma in the elderly: a population-based study. Patients with newly diagnosed AACG—between 1 January 2013 and 31 December 2016—who had received at least one BZD prescription prior to AACG diagnosis were enrolled. - 54.39.16.118. The objective of this study was to assess whether the use of BZDs is associated with the risk of AACG. Psychiatry Res. Prevention and treatment information (HHS). We performed a case-control study using a geriatric cohort from the National Health Insurance database (2002-2013) in Korea. Alle Benzodiazepinebesitzen eine bicyclische Grundstruktur aus einem siebengliedrigen ungesättigten Ring, an dem noch ein Benzolring anelliert ist. Chen HY, Lin CL, Lai SW, Kao CH. Glaucoma is found among people who take Clonazepam, especially for people who are female, 60+ old, have been taking the drug for < 1 month. Results: Dordrecht: Springer; 1985. p. 43–58. 2003;26:749–67. Benzodiazepine sind Wirkstoffe in Medikamenten. 2019 Sep-Dec;13(3):104-109. doi: 10.5005/jp-journals-10078-1261. 2012;45:217–22. In den Warenkorb. PubMed Alle chemisch definierten Hypnotika könnten bei längerer Einnahme Toleranz … 2012;32:403–7. CNS Drugs. Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, Republic of Korea, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do, Republic of Korea, Department of Health Administration, Kongju National University College of Nursing and Health, Gongju-si, Chungcheongnam-do, Republic of Korea, Department of Psychiatry, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea, You can also search for this author in DOI: 10.1007/s40264-020-00914-7 Corpus ID: 211054059. Seong SC, Kim Y-Y, Khang Y-H, Park JH, Kang H-J, Lee H, et al. i don't know the answer to your question, but i was curious and found this on diazepam (valium) contraindications / precautions "diazepam is contraindicated in patients with closed-angle glaucoma. Ein weiteres Problem ist die Toleranzentwicklung (Gewöhnungseffekt). 2007;18:129–33. Benzodiazepine Use and Risk of Acute Angle-Closure Glaucoma: A Population-Based Case-Crossover Study ConclusionWe found that BZD use was associated with AACG risk in the Korean population. Lai JS, Gangwani RA. 2011;124:20–5. Sie fanden urspr… However, there is no research evidence for the association between BZDs and AACG, except two case reports. Drug Safety Acute angle-closure glaucoma; Aged; Benzodiazepines; Case-control design; Pharmaco-epidemiology; Population-based study. Park MY, Kim WJ, Lee E, Kim C, Son SJ, Yoon JS, et al. Richa S, Yazbek J-C. Ocular adverse effects of common psychotropic agents: a review. Objective: We used conditional logistic regression that adjusted for concomitant medications to determine the odds ratio for the use of BZDs in the case period compared with that in the control period in patients with incident AACG. Benzodiazepine Use and Risk of Acute Angle-Closure Glaucoma: A Population-Based Case-Crossover Study. 1992;33:271–7. Methods: Answer: Benzodiazepines can dilate the pupil, so it is conceivable that they could cause problems in a patient with narrow-angle glaucoma.For patients with open-angle glaucoma, the use of benzodiazepines should not present a problem.Please check with your ophthalmologist if you are unsure what type of glaucoma you have. © 2021 Springer Nature Switzerland AG. J Psychosom Res. 2018;6:43. J Clin Psychiatry. eCollection 2020. Association of selective serotonin reuptake inhibitor use and acute angle-closure glaucoma. National Library of Medicine 8600 Rockville Pike J Clin Psychiatry. Theoretically, benzodiazepines (BZDs) can narrow the iridocorneal angle and induce acute angle-closure glaucoma (AACG). Kim WJ, Li J, Oh IS, Song I, Lee E, Namkoong K, Shin JY. However, little evidence exists regarding this association. Continuation and discontinuation of benzodiazepine prescriptions: a cohort study based on a large claims database in Japan. Martinsson G, Fagerberg I, Wiklund-Gustin L, Lindholm C. Specialist prescribing of psychotropic drugs to older persons in Sweden-a register-based study of 188,024 older persons. Because benzodiazepines (BZDs) can affect pupillae muscles, their use could be a risk factor for acute angle-closure glaucoma (AACG), which is an ophthalmic emergency. Der Prototyp ist das Diazepam. 1. Insbesondere bei älteren Menschen kann dies zur Akkumulation führen. Below is the link to the electronic supplementary material. 2017;46:e15. Tafil Pfizer 0,5 mg 100 Stk. We found that BZDs increase the risk of AACG at the beginning of its use among the Korean elderly. Unilateral Acute Angle-Closure Glaucoma After Lumbar Spine Surgery: A Case Report and Systematic Review of the Literature. Drug Saf. Bilateral angle closure glaucoma and visual loss precipitated by antidepressant and antianxiety agents in a patient with depression. Kwon J. Clinicians should carefully monitor the occurrence of visual disturbance in BZD-treated patients. Die Medikamente können … Seoul: National Evidence-based Healthcare Collaborating Agency; 2012. http://policy.nl.go.kr/cmmn/FileDown.do;jsessionid=x4PV3W7N24rVG8lGBSydalS4vfwZr9fx1nBY0FZGED6D7DxM00VEH03vXry3GYVP.sl-extwas_servlet_engine5?atchFileId=213170&fileSn=54856. Benzodiazepine wirken verstärkend auf die GABAA-Rezeptoren des Nervensystems. Einige Vertreter dieser Verbindungen haben als Arzneimittel eine große Bedeutung. Dies bringt die Gefahr einer Abhängigkeit ohne … Was sind die Nebenwirkungen? Ju-Young Shin. Benzodiazepine und Sucht: Benzo-Abhängigkeit ist häufig. Google Scholar. Hyams SW, Keroub C. Glaucoma due to diazepam. The first benzodiazepine was synthesised by accident in 1955 in the laboratories of Hoffman-La Roche and has since become the most widely prescribed drug in the world. Midazolam, Diazepam) are contraindicated in patients with acute narrow angle glaucoma because they can increase intra-ocular pressure. Benzodiazepine binden an die GABA-Rezeptoren und verändern dadurch ihre Struktur geringfügig, so das sie leichter durch GABAaktiviert werden können. The date of AACG diagnosis was set as the index date. Im Szenejargon werden sie „Benzos“, „Xanax“ (Alprazolam), „Rohpies“ (Rohypnol), „Flunies“ (Flunitrazepam) und „Dias“ (Diazepam) genannt. benzodiazepine and become agitated and have psychomotor restlessness, but this adverse effect rarely occurs.4 Benzodiazepines should not be used if the patient has angle-closure glaucoma, ataxia, chronic respiratory insufficiency, myasthenia gravis, sleep apnea, spinal and cerebellar ataxia, or intoxication with a central nervous J Clin Epidemiol. the mechanistic rational for this contraindication has been questioned, as benzodiazepines do not have antimuscarinic activity and do … To examine the risk of BZD use for AACG, we performed conditional logistic regression analyses with potential confounders including comorbidities and concomitant medication. Accessed 1 Mar 2019. Eine besonders dramatische Nebenwirkung bei der Langzeitbehandlung mit Benzodiazepinen ist die Sucht. Copyright © 2019 Elsevier Inc. All rights reserved. Curr Neuropharmacol. 2020 Jun;43(6):539-547. doi: 10.1007/s40264-020-00914-7. J Clin Psychopharmacol. doi: 10.4088/JCP.15m10038. Bethesda, MD 20894, Copyright Theoretically, benzodiazepines (BZDs) can narrow the iridocorneal angle and induce acute angle-closure glaucoma (AACG). 4-8 Wochen) auch in der vom Arzt vorgeschriebenen Dosierung schwer körperlich und psychisch abhängig. Seitz DP, Campbell RJ, Bell CM, Gill SS, Gruneir A, Herrmann N. Short-term exposure to antidepressant drugs and risk of acute angle-closure glaucoma among older adults. The benzodiazepines: current standards for medical practice. Benzodiazepine und Z-Drugs verlieren bei regelmässiger Einnahme ihre Wirkung. However, little evidence exists regarding this association. J Curr Glaucoma Pract. Am J Epidemiol. Int J Epidemiol. Kadoi C, Hayasaka S, Tsukamoto E, Matsumoto M, Hayasaka Y, Nagaki Y. Kim, W.J., Li, J., Oh, IS. 2004;57:1288–94. Abrupt cessation of benzodiazepine therapy may precipitate seizures and other withdrawal symptoms, particularly after prolonged use and/or excessive dosages. Benzodiazepine führen darüber hinaus zu einer Wirkungsverstärkung anderer zentral dämpfender Pharmaka. Benzodiazepine sind psychoaktive Substanzen, die in erster Linie als Schlafmittel, Beruhigungsmittel, Angstlöser und Antikonvulsiva eingesetzt werden. 37.90 € Wirkstoff: Alprazolam. Bei der Metabolisierung entstehen teilweise aktive Metaboliten mit langer HWZ, zum Beispiel Desmethyl-Diazepam mit etwa 90 Stunden. 10th ed. Eye (Lond). Ooba N, Iwahashi R, Nogami A, Nakayama T, Kanno A, Tochikura N, Ootsuka S, Fukuoka N. PLoS One. Please enable it to take advantage of the complete set of features! Short-term exposure to antidepressant drugs and risk of acute angle-closure glaucoma among older adults. [Acute glaucoma episode improved by a benzodiazepine: dipotassic clorazepate]. 1991;133:144–53. Theoretically, benzodiazepines (BZDs) can narrow the iridocorneal angle and induce acute angle-closure glaucoma (AACG). Correspondence to Invest Ophthalmol Vis Sci. Long-term benzodiazepine use in patients with major depressive disorder in China. 2012 Jun;32(3):403-7. doi: 10.1097/JCP.0b013e31825420a1. Costagliola C, Parmeggiani F, Semeraro F, Sebastiani A. https://doi.org/10.1007/s40264-020-00914-7, DOI: https://doi.org/10.1007/s40264-020-00914-7, Over 10 million scientific documents at your fingertips, Not logged in FOIA 2017;46:799–800. Diese Wirkstoffe kann man in zwei Gruppen unterteilen: Beruhigungsmittel (Sedativa/ Tranquilizer) und zum anderen in Schlafmittel (Hypnotika). 2019;60:1028–43. The objective of this study was to assess whether the use of BZDs is associated with the risk of AACG. Qatar Med J. Tripathi RC, Tripathi BJ, Haggerty C. Drug-induced glaucomas: mechanism and management. Status epilepticus may occur in patients with a history of seizures withdrawn rapidly from benzodiazepine therapy.
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