Log In. Speed of therapeutic onset is comparable (almost identical) to IV administration, generally achieving peak plasma levels of drug in 2 to 5 minutes. perchè una è una parola e l altra son 2, se scrivi "tutto staccato" vedi che son 2 STACCATO Flats Series. STACCATO Season Lookbook. Performed for the Hindu November Fest 2018 at Chennai, Bengaluru & Hyderabad. The interior of the upper part of the instrument is inscribed with Maria's initials, Italsko-Äeský slovník zdarma. A single inhalation actuates the Staccato OBT system and delivers the drug. Dose delivery by Staccato OBT does not require priming, hand/breath coordination, or forceful inhalation—the aerosol is simply generated and entrained in the patient's breath. The key to our proprietary technology is vaporization of drug without thermal degradation achieved by rapid heating of the drug film to generate consistent aerosol particles of 1–5 microns in size that are optimal for deep lung inhalation; it is not dependent on mechanics or preformed drug particles to create drug aerosols. Staccato’s Clients include Saint Gobain, TNPL, Madras Cricket Club, TVS, Sanmar, Standard Charted Bank ,The Hindu, Young Indians, etc. Conjugation Documents Grammar Dictionary Expressio. Therefore, that information is unavailable for most Encyclopedia.com content. Facebook. agg. The drug is vaporized off the substrate within 500 milliseconds and drawn into the patientâs lungs within 1 second for absorption into systemic circulation. Corporate Headquarters Moeser. Thus, if there is an existing IV formulation for the compound of choice, then that is the most appropriate dose for the Staccato OBT. . Our commercial product ADASUVE (loxapine) inhalation powder (ADASUVE.com) and drug product candidates in our pipeline have demonstrated statistically significant onset of therapeutic effect within 10 minutes. The Staccato device is breath actuated. The Staccato OBT devices can incorporate multiple features, including lockout to enhance safety, the convenience of patient titration, and a variety of dose administration regimens. :) Answer Save. Knihy VypoÅ¥te své modlitby - Pohyb jako duchovní praxe-- autor: Roth Gabrielle Kapry bijem-- autor: Pilipiuk Andrzej Lv 5. The Staccato OBT system can be customized to enhance safety and security to accommodate a variety of dose administration regimens including: Staccato OBT products are designed with patients’ use in mind. The dose cartridge contains up to 25 doses coated onto individual metal substrates, Each metal substrate rapidly heats upon application of battery-supplied electric current and can be coated with micrograms of drug compound, Consists of a reusable controller and a disposable dose cartridge. Driven by zeal and passion to explore and learn new forms of music and incorporating our cultural roots make Staccato a very unique band from Chennai. At this first time point measured, patients with underlying schizophrenia and bipolar disorder taking Staccato loxapine showed significant improvement in their agitation symptoms versus placebo. Email or Phone: Password: Forgot account? The development team at Alexza designed the Staccato OBT devices with the patient in mind. staccato definition: 1. used to describe musical notes that are short and separate when played, or this way of playingâ¦. In addition, particle size optimization is often performed in order to assure deep lung delivery. For dose delivery by the Staccato OBT system, no priming, hand/breath coordination, or forceful inhalation is required—the aerosol is simply entrained in the patient’s breath. Learn more. Some of our notable performances at prestigious venues are as follows: Double Edge is the celebration of two similar but distinct sounds that emanate from Chennai and celebrate all things global, In one evening, two bands delve into their Carnatic roots, then spin fresh, spirited melodies, The band members of Staccato explain what makes their original compositions & signature rejigs of established tracks, stand out, Chennai-based band Staccato played to thunderous applause over the weekend, The band stayed true to being all-round entertainers at the global concert series, Staccato and Indosoul have their own stylistic identities in contemporary presentations, Chennai-based Staccato is elated over being selected to perform at the Olympics in London, Finding an audience of different age groups enjoying a similar genre of music can sometimes be rare, For Enquiries - contactstaccato@gmail.com, The only band to have been chosen from India to perform at the 2012 London Olympics. These aerosol particles are rapidly absorbed, resulting in peak plasma blood levels obtained in the first few minutes after administration. Moreover, molecular weight is usually key, in that macromolecules, peptides, and proteins generally do not work in our technology. Význam: krátce, oddÄlovanÄ, odráženÄ . Staccato na Zalando UK | Objevte velký výbÄr a využijte bezplatné dopravy a vrácení zboží zdarma | Objednejte Staccato na Zalando hned teÄ! The aerosol produced with the Staccato OBT system is designed to be absorbed rapidly through the deep lung. See more of Favij on Facebook. Titular character Johnny Staccato, played by John Cassavetes, is a jazz pianist/private detective. A single inhalation actuates the Staccato OBT device and delivers the drug. Výslovnost: stakato. Rychlý pÅeklad slova staccato do ÄeÅ¡tiny, výslovnost, tvary a pÅíklady užití. Synopsis. A staccato ellentéte a legato, mely hosszan kitartott, folytonos játékmódot jelent. Represented India at the World Freestyle Percussion event ‘Tum Tum Pa’ conducted by Redbull at Rio De Janerio, Brazil. Han var en mand, der levede i staccato, som talte, løb ind og ud af døre og aldrig blev siddende i en stol mere end et kvarter Pol1987 Politiken (avis), 1987. Staccato OBT products are designed with patients in mind. After vaporization, the drug cools rapidly in air, condensing into pure drug aerosol particles of near ambient temperature. Staccato is a Chennai based band, popularizing the genre Contemporary Classic, keen on giving an experiential listening to its audience. Infatti non dici mai ho "tutto attaccato" la spina della corrente, bensì ho attaccato la spina. A dire il vero "staccato" è il contrario di "attaccato", e non di "tutto attaccato". Rapid heating of a thin film of excipient-free drug creates a drug aerosol without thermal degradation. Staccato je styl hudebního pÅednesu, kdy jsou jednotlivé tóny hrány s co nejvýraznÄjÅ¡ím oddÄlením. A variety of functional groups may be acceptable depending on their particular molecular arrangement as well as other physical and chemical properties of the drug. Rapid vaporization of a pure drug film (rather than mechanically generating aerosols or utilizing preformed particles) enables consistent generation of particles averaging 1â5 microns in size, optimal for deep lung inhalation. After vaporization, the drug cools rapidly in air, condensing into pure drug aerosol particles of near ambient temperature. Rapportér et problemfra Den Danske Ordbog Den Danske Ordbog. In the pivotal studies with ADASUVE® (loxapine) inhalation powder (Staccato loxapine), statistically significant onset of effect was observed as early as 10 minutes after dosing. :(Answer Save. Filter by Custom Post Type. Help me! avvolte (tutto attaccato) se ti riferisci al verbo "avvolgere",altrimenti se vuoi dire qualche volta è(staccato) 1 1. melissabasilici. Filter by Product categories Email Us, Approved (FDA and EMA) drug delivery system, Demonstrated efficient clinical development, Proven core technology enables rapid design, development, and transfer into commercial manufacturing, Consists of a metal substrate that is heated through an exothermic chemical reaction, The substrate can be coated with milligrams of drug compound, Consists of a reusable controller and a disposable dose cartridge. Learn more. Two Phase 1 clinical studies with our migraine and breakthrough pain programs have directly compared delivery of the same dose by IV and Staccato OBT. 1. p.pass. Sections of this page. Alexza has demonstrated that for the products tested to date, peak plasma levels have been achieved within 2 to 5 minutes of inhalation. Unlike many other inhalation technologies, the patient does not need to coordinate inhalation with other actions, and the patient does not need to learn a special breathing pattern. Io solitamente lascio la spina attaccata ma stacco l'altra estremità del cavo dall' alimentatore mentre il 2° cavo (quello che attacca alimentatore a Xbox) lo lascio attaccato. dipende dal significato: se è per dire "qualche volta" allora si scrive "a volte". AVE MARIA (v. Elizabeth Mulliner) T554-1 (A-2447) MAJ1108-07/? Il vero contrario di "tutto attaccato" è "tutto staccato", quindi la tua domanda è ⦠Co znamená staccato? When the patient draws a breath through the Staccato OBT system, the substrate surface instantaneously heats to create a condensation aerosol. A large number of molecules have demonstrated technical feasibility with Staccato technology. The Staccato OBT system generates optimally sized aerosolized drug particles with consistent particle size distribution. The Staccato OBT system generates optimally sized aerosolized drug particles with consistent particle size distribution. Accessibility Help. All Staccato OBT devices are designed to actuate with minimal inhalation effort. 1 decade ago. Filter by Custom Post Type. The profiles indicated that the Staccato OBT generates PK profiles very similar (almost identical) to IV, with the same bioavailability and peak plasma levels. Generovaný, orientaÄní výÄet dalÅ¡ích tvarů tohoto slova. staccato. způsob hry angliÄtina: staccato francouzÅ¡tina: staccato m nÄmÄina: Staccato s Based on our experience with the screened compounds, an initial assessment can be made as to whether a particular drug will generate an aerosol with an acceptable purity profile. Sign Up. L' alimentatore va staccato o attaccato?? Rapid heating ensures minimal thermal decomposition. It is known as Bisogna distinguere a seconda della categoria grammaticale. See more of Favij on Facebook. favi ma perchè tutto attaccato si scrive staccato e staccato si scrive tutto attaccato? To use Staccato OBT, a patient simply places the device to their lips and inhales (there is no waiting or prep time). After the initial feasibility study, the path to IND will often depend on conducting IND-enabling inhalation toxicology studies and optimizing the delivery platform for a specific compound. ⦠If the drug compound has already been approved in a formulation such as oral or IV, a 505(b)(2) regulatory strategy may be considered for a Staccato OBT product. [5] (The King's Theatre, the second on this site, eventually became Her Majesty's Theatre, where Phantom of the Opera has enjoyed a long run in London. Buonanotte o buona notte: si scrive attaccato o staccato, qual è la regola dell'Accademia della Crusca e i dubbi su buongiorno. More. The Staccato OBT system can deliver both water-soluble and water-insoluble compounds without the need for excipients and additives such as detergents, stabilizers, and solvents, enabling the delivery of unformulated drug. Translation Spell check Synonyms Conjugation. The vaporized drug cools and condenses into pure drug aerosol particles. The patient inhales optimally sized particles of pure drug down into the narrower, more vascularized tissue of the deep lung, allowing fast and more complete absorption into the bloodstream for rapid systemic effect. The Staccato OBT products are reviewed as drug products by the FDA’s Center for Drug Evaluation and Research division. A két ellentét között megkülönböztetnek egy köztes esetet is, melyet a szaknyelv mezzo staccatónak nevez.. A vonósok számára elÅírt staccato vonóval adandó elÅ, azaz nem a pizzicato egyik válfaja. See more. ALEXZA PHARMACEUTICALS Filter by Product categories Staccato definition, shortened and detached when played or sung: staccato notes. TEL: 650 944 7000 The Staccato OBT system is suited for delivery of drug combinations (e.g., two different actives). To find out if your compound will work in the Staccato OBT system, please contact our Business Development Group. Obvykle tón netrvá po celou zapsanou délku noty, ale je zkrácen a zbytek trvání noty nahrazen pauzou. There is no general rule. Because the duration of drug heating is so brief, thermal decomposition is minimal. Reverso for Windows. If the compound is delivered orally, the compound’s bioavailability and metabolism will determine the Staccato OBT dose. Johnny Staccato is an American private detective series starring John Cassavetes which ran for 27 episodes on NBC from September 10, 1959 through March 24, 1960. A screening feasibility study can be performed to determine a molecule's feasibility for thermal vaporization. Log In. Update: Ovviamente intendo a Console spenta!! The Staccato OBT system delivers a consistent dose across a wide range of inhalation styles. Obvykle tón netrvá po celou zapsanou délku noty, ale je zkrácen a zbytek trvání noty nahrazen pauzou.. Staccato se v notovém zápisu oznaÄuje teÄkou nad nebo pod notou. good morning - Traduzione del vocabolo e dei suoi composti, e discussioni del forum. In less than half a second, the drug is heated to a temperature sufficient to convert the solid drug film into a vapor. They fulfill a significant unmet medical need by providing new treatment options to patients and physicians. The Staccato OBT system matches delivery characteristics and product attributes to patient needs for rapid and effective treatment of acute and intermittent conditions. Onset of action is more rapid compared to other drug delivery methods such as oral tablets, fast-dissolve tablets, sublingual films, and intramuscular and subcutaneous injections. Rapid peak plasma levels with a simple breath. The Alexza clinical team has conducted a number of clinical studies with Staccato OBT products where speed of onset has been evaluated. Have performed in London , Rio De janerio , Muscat, Malaysia , Bali and all over India. This experience promises new age interpretation of Carnatic Classical Krithis, seamless amalgamation of nostalgic film music with a contemporary twist and mellifluous originals composed for social causes that has been well received by the band’s fans and followers. The Staccato OBT devices meet the need of different therapeutic treatments. Immediate absorption of the drug results in rapid onset of action and therapeutic effect. FAX: 650 944 7999 The Staccato OBT system comprises the rapid vaporization of an excipient-free drug to form aerosol particles optimal for systemic delivery through inhalation. Staccato OBT products generate a pharmacokinetic profile similar (almost identical) to IV delivery while delivering medicine in a non-invasive way. Staccato je styl hudebního pÅednesu, kdy jsou jednotlivé tóny hrány s co nejvýraznÄjÅ¡ím oddÄlením. Staccato performs for Music Festivals, Concerts, Corporate Gigs, Cultural events, and Social events. or. Staccato is a Chennai based band, popularizing the genre Contemporary Classic, keen on giving an experiential listening to its audience. Veramente non riesco a capirlo!!! Ma se "tutto attaccato" si scrive staccato, perchè "staccato" si scrive tutto attaccato?? Perché "tutto attaccato" si scrive staccato, mentre "staccato" si scrive tutto attaccato? In less than half a second, the drug is heated to a temperature sufficient to convert the solid drug film into a vapor. Alimentatore Xbox 360 staccato o attaccato? Press alt + / to open this menu. 2091 Stierlin Court Det Danske Sprog- og Litteraturselskab 2018. Perché tutto attaccato si scrive staccato mentre staccato si scrive tutto attaccato? Translations in context of "staccato" in Italian-English from Reverso Context: si è staccato, staccato la testa, staccato la spina, staccato dal, quasi staccato. The unique feature of the Staccato OBT is achievement of a consistently delivered fine particle dose regardless of the patient's breathing pattern. The Staccato OBT products generate a PK profile generally observed by IV delivery (i.e., same Tmax and Cmax). The Staccato OBT system delivers pure (unformulated) drug, which reduces development time as formulation development is not required. Create New Account. Mountain View, CA 94043 Clinical studies with a number of Staccato OBT product candidates have demonstrated patient compliance and confirmed that the intuitive nature of inhaling in a single breath to receive the dose is suitable for patients with acute conditions. Compounds from many different therapeutic areas have shown initial vaporization feasibility. In addition to delivering aerosol from a single active compound, the Staccato technology can also be used for delivery of a combination of different actives in a single breath. Alexza has completed feasibility testing of over 400 compounds, approximately half of which have demonstrated positive initial vaporization feasibility, resulting in high-purity aerosols when vaporized at an appropriate film thickness and temperature. Staccato ([stakËkaËto]; Italian for "detached") is a form of musical articulation.In modern notation, it signifies a note of shortened duration, separated from the note that may follow by silence. CIVIUM. Compounds with low bioavailability and high first-pass hepatic metabolism will most likely have a significantly reduced dose in a Staccato OBT. Jump to. It has been described by theorists and has appeared in music since at least 1676. Un conto è infatti il trattamento dellâinteriezione (il saluto, in buona sostanza), un altro conto è il trattamento grafico del sostantivo. Pick a style below, and copy the text for your bibliography. Význam slova staccato ve slovníku cizích slov vÄetnÄ pÅekladů do angliÄtiny, francouzÅ¡tiny a ruÅ¡tiny. to p.pass., agg., s.m. The heart of the hand-held Staccato OBT system is a heated stainless steel substrate, onto which a thin film of unformulated drug is coated. Rapid vaporization of a pure drug film (rather than mechanically generating aerosols or utilizing preformed particles) enables consistent generation of particles averaging 1–5 microns in size, optimal for deep lung inhalation. The dose cartridge contains a single dose of a drug in milligram quantities, Each metal substrate rapidly heats upon application of battery-supplied electric current, Thin film of unformulated drug coated on the substrate, Breath activation—senses inhalation to automatically trigger aerosol generation, Dosing lockout features to prevent overdose and to manage patient titration, Wireless (Bluetooth) communication for patient monitoring and dose tracking. â staccare, staccarsi 2a. Se è il participio passato del verbo "avvolgere" allora si scrive attaccato⦠staccato meaning: 1. used to describe musical notes that are short and separate when played, or this way of playingâ¦.
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